The quality and experience of healthcare systems affect the economy and prosperity of cities all over the world. Governments of several countries are struggling to improve the efficiency of their healthcare systems and decrease healthcare spending costs. In this paper, we discuss one of the most critical and busy processes among healthcare topics: ambulatory care center (ACC) appointment scheduling systems. We investigate the appointment-scheduling issue using a robust optimization framework to minimize operational costs while ensuring the improvement of healthcare service quality. Our findings and insights provide healthcare practitioners with tools to improve operational efficiency and service quality.