This paper is concerned with the Cauchy problem of the one-dimensional compressible Navier-Stokes equations with degenerate temperature dependent transport coefficients which satisfy conditions from the consideration in kinetic theory. A result on the existence and uniqueness of a globally smooth nonvacuum solution is obtained provided that the (γ − 1) · (H 3 (R)-norm of the initial perturbation)< C for some positive constant C independent of γ − 1. Here γ > 1 is the adiabatic gas constant. This is a Nishida-Smoller type global solvability result with large data.

Mitochondrial aldehyde dehydrogenase (ALDH2) is known to offer myocardial protection against stress conditions including ischemia-reperfusion injury, alcoholism and diabetes mellitus although the precise mechanism is unclear. This study was designed to evaluate the effect of ALDH2 on diabetes-induced myocardial injury with a focus on autophagy. Wild-type FVB and ALDH2 transgenic mice were challenged with streptozotozin (STZ, 200mg/kg, i.p.) for 3months to induce experimental diabetic cardiomyopathy. Diabetes triggered cardiac remodeling and contractile dysfunction as evidenced by cardiac hypertrophy, decreased cell shortening and prolonged relengthening duration, the effects of which were mitigated by ALDH2. Lectin staining displayed that diabetes promoted cardiac hypertrophy, the effect of which was alleviated by ALDH2. Western blot analysis revealed dampened autophagy protein markers including LC3B ratio and Atg7 along with upregulated p62 following experimental diabetes, the effect of which was reconciled by ALDH2. Phosphorylation level of AMPK was decreased and its downstream signaling molecule FOXO3a was upregulated in both diabetic cardiac tissue and in H9C2 cells with high glucose exposure. All these effect were partly abolished by ALDH2 overexpression and ALDH2 agonist Alda1. High glucose challenge dampened autophagy in H9C2 cells as evidenced by enhanced p62 levels and decreased levels of Atg7 and LC3B, the effect of which was alleviated by the ALDH2 activator Alda-1. High glucose-induced cell death and apoptosis were reversed by Alda-1. The autophagy inhibitor 3-MA and the AMPK inhibitor compound C mitigated Alda-1-offered beneficial effect whereas the autophagy inducer rapamycin mimicked or exacerbated high glucose-induced cell injury. Moreover, compound C nullified Alda-1-induced protection against STZ-induced changes in autophagy and function. Our results suggested that ALDH2 protects against diabetes-induced myocardial dysfunction possibly through an AMPK -dependent regulation of autophagy. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases.

In this paper, we study the global solutions with large data away from vacuum to the Cauchy problem of the one-dimensional compressible Navier-Stokes-Poisson system with density-dependent viscosity coefficient and density-and temperature-dependent heat-conductivity coefficient. The proof is based on some detailed analysis on the bounds on the density and temperature functions.

Indexing and ranking are two key factors for efficient and effective XML information retrieval. Inappropriate indexing may result in false negatives and false positives, and improper ranking may lead to low precisions. In this paper, we propose a configurable XML information retrieval system, in which users can configure appropriate index types for XML tags and text contents. Based on users' index configurations, the system transforms XML structures into a compact tree representation, Ctree, and indexes XML text contents. To support XML ranking, we propose the concepts of "weighted term frequency" and "inverted element frequency," where the weight of a term depends on its frequency and location within an XML element as well as its popularity among similar elements in an XML dataset. We evaluate the effectiveness of our system through extensive experiments on the INEX 03 dataset and 30 content and structure (CAS) topics. The experimental results reveal that our system has significantly high precision at low recall regions and achieves the highest average precision (0.3309) as compared with 38 official INEX 03 submissions using the strict evaluation metric.