Background: Pancreatic cancer ranks as the fourth leading cause of cancer-related mortality in the USA. And gemcitabine has been the standard of care for advanced pancreatic cancer. However, a combined use of gemcitabine plus cisplatin (GemCis) has shown promising efficacies in pancreatic cancer patients. Here, system review and meta-analysis were performed to compare the efficacy and safety of GemCis versus gemcitabine (Gem) alone in the treatment of pancreatic cancer. Methods: The databases of MEDLINE (PubMed), EMBASE, and Cochrane Library were systematically searched for retrieving the relevant publications prior to 31 September 2014. The primary end point was overall survival (OS) and secondary end points included 6-month survival, 1 year survival, overall response rate (ORR), clinical benefit rate (CBR), time to progression/progression-free survival (TTP/PFS), and toxicities.

This work demonstrates the generation of the noise-like pulse (NLP) in an all-normal-dispersion passively mode-locked ytterbium-doped ring laser cavity with nonlinear multimodal interference as an equivalent all-fiber saturable absorber, for the first time to the best of our knowledge. Depending on the appropriate optimization of the intra-cavity birefringence and reasonable control of the curving curvature of the multimode fiber, self-started NLP operation can be built and maintained within a wide pump range. Additionally, the effect of the multimode fiber length on the NLP mode-locking performance and the generation of the high power NLP have also been experimentally studied.

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