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We aimed to identify the molecular biomarkers of MDD disease progression to uncover potential mechanisms of major depressive disorder (MDD). In this study, three microarray data sets, GSE44593, GSE12654, and GSE54563, were cited from the Gene Expression Omnibus database for performance evaluation. To perform molecular functional enrichment analyses, differentially expressed genes (DEGs) were identified, and a protein–protein interaction network was configured using the Search Tool for the Retrieval of Interacting Genes/Proteins and Cytoscape. To assess multi-purpose functions and pathways, such as signal transduction, plasma membrane, protein binding, and cancer pathways, a total of 220 DEGs, including 143 upregulated and 77 downregulated genes, were selected. Additionally, six central genes were observed, including electron transport system variant transcription factor 6, FMS-related receptor tyrosine kinase 3, carnosine synthetase 1, solute carrier family 22 member 13, prostaglandin endoperoxide synthetase 2, and protein serine kinase H1, which had a significant impact on cell proliferation, extracellular exosome, protein binding, and hypoxia-inducible factor 1 signaling pathway. This study enhances our understanding of the molecular mechanism of the occurrence and progression of MDD and provides candidate targets for its diagnosis and treatment.

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Two new complexes constructed by 1,4-phenylenediacetic acid (H 2 PDA) and 2,2 -bipyridine (2,2 -bpy), namely [Cu(PDA)(2,2 -bpy)]·5H 2 O (1) and [Zn 2 (PDA)( 2,2 -bpy) 2 Cl 2 ] (2), have been synthesized and characterized by single-crystal X-ray diffraction, elemental analysis, IR, and UV-Vis spectrum. Single-crystal X-ray diffraction reveals that they both crystallize in the triclinic space group of P-1. In complex 1, the Cu atom is hexa-coordinated and each asymmetric unit contains five uncoordinated water molecules that form a water cluster (H 2 O) 10 with their symmetric equivalent. Complex 2 is a simple dimer and the Zn atom is penta-coordinated. Both in complex 1 and 2 there are π−π stacking interactions. INTRODUCTIONRecently, much attention has been paid to the synthesis of coordination polymers due to their potential applications such as gas storage, selective catalysis, molecular separation, and magnetism. [1−8] As far as we know, selecting appropriate ligands is the most effective strategy in obtaining coordination polymers. As bridging ligands, carboxylates, especially multi-carboxylates, are of immense interest in the construction of polymeric coordination architectures not only because the fact that these polymers have a wide range of structural diversities and potential applications as porous materials and magnetic materials, but also because the multi-carboxylates are capable of functioning as hydrogen bond donors and/or