Purpose: To examine the prevalence of Compassion Fatigue and Compassion Satisfaction and correlate them with Social Support among oncology nurses in Pakistan. Design: Quantitative, descriptive, cross-sectional study. Methods: The population size is 344 participants. an online survey was conducted using a simple random convenience sampling method to select the participants from different oncology hospitals of province Punjab, Pakistan. An equal chance of selection will be given to each participant. A survey was used to collect the data, which was then examined using descriptive statistics and the Pearson correlation coefficient. This study employed the social support scale and the Professional Quality of Life scale version 5. Research Variables: Compassion satisfaction（CS）, Burnout（BO）, Secondary traumatic stress（STS）, and Social support（SS） Findings: Demographics data shows that those with graduate and master's degrees nurses have a good level of CS and a lower level of BO than those with only a nursing diploma. When CS and Compassion Fatigue were correlated with SS, it was observed that BO and STS are substantially correlated with supervisors and management, whereas CS is highly correlated with family and friends. Conclusions: Oncology is a stressful field compared to other departments, and a healthy and supportive environment is needed for nurses to work and enjoy their professional lives. Hospital management needed to conduct seminars, and training programs for nurses to sort out their stress and patient disease management.