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On the foundation of nonlinear robust control and exact generator model, this paper presents a design principle of NR-PSS (Nonlinear Robust Power SystemStabilizer) for multi-machine power system, based on which an industrial NR-PSS equipment is developed. For popularizing it, the proposed parameter setting method of NR-PSS is completely the same as the widely used parameter adjustment rule of PSS. By virtue of real time digital simulator (RTDS), large disturbance experiments are carried out to compare the performances between generator excitation system equipped with NR-PSS and PSS in order to verify the correctness of design theory. The results show that compared with classical PSS, the proposed NR-PSS can dramatically improve the generator damping and attenuate the oscillation much faster, enhance the generator damping and raise both the small signal and large disturbance transient stability transmission power limit remarkably. The NR-PSS equipment with independent intellectual property right has been successfully put into operation on a 300 MW generator in Baishan Hydro Plant of Northeast China Grid more than 10 months. nonlinear robust control, power system stabilizer, real time digital simulation system, large disturbance experiments "Safety First" has always been emphasized in power system management and dispatching in China, especially these years. As is well known to all, advanced excitation control of large synchronous generators is one of the most effective and economical ways to elevate the security and stability level of power grid operation. With the wide use of fast exciter (self shunt exciter mode) of generators in the USA in 1960s, the basic contradiction in the engineering control, i.e. the con-

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Background. Vaspin is an important adipokine that is involved in cardiovascular diseases. This study is aimed at investigating whether vaspin participates in sepsis-induced cardiac injury and explored the possible mechanism. Methods. First, cecal ligation and puncture (CLP) and lipopolysaccharide (LPS) were used to establish a mouse model of sepsis, and cardiac vaspin expression was examined. In addition, after pretreatment with vaspin or phosphate-buffered saline (PBS), wild-type (WT) mice underwent CLP to establish a septic model and received sham as a control. Finally, WT mice and kallikrein 7 (KLK7-/-) mice were underwent CLP with or without vaspin pretreatment. Results. Mice that underwent CLP and were administered LPS exhibited increased vaspin expression in both the heart and serum compared with sham- or saline-treated mice. In CLP mice, pretreatment with vaspin reduced mortality and alleviated the expression of cardiac injury markers and cardiac dysfunction. In addition, vaspin reduced the cardiac levels of CD45+ cells and CD68+ cells, alleviated the cardiac inflammatory response, and reduced cardiomyocyte apoptosis. The protective effects of vaspin on CLP mice were masked by the deletion of KLK7, which was demonstrated to be a downstream signal of vaspin. Conclusions. Vaspin alleviates cardiac inflammation and plays a protective role in sepsis-induced cardiac injury by reducing KLK7 expression.