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This study includes complete information on Shenmai injection ADR incidence rate. We found that Shenmai injection is safe and this study can provide clinical, research, and production institutions with an objective, reliable, and scientific basis for use of Shenmai injection.

Prospective, multi-center, large-sample and registered design was used to analyze the drug combination features of Shenqi Fuzheng injection in the real world clinical application, and comprehend the drug combination in the real world. A total of 30 026 patients with the use of Shenqi Fuzheng injection were registered, where the chemical drugs were used for 57 436 times (accounting for 82.76%), and the Chinese patent medicines were used for 11 962 times (accounting for 17.24%), mainly including anti-acid drugs and anti-ulcer drugs, nutritional agent, immune enhancement agent, etc. According to the association rules, drug combinations of 2 drugs were closely related to inhibiting gastric acid secretion and anti-tumor; drug combinations of 3 drugs were closely related to inhibiting gastric acid secretion, antiemetic and anti tumor; drug combinations of 4 drugs were closely related to inhibiting gastric acid secretion, antiemetic, anti-tumor, and immune enhancement. The above results were consistent with the Instruction, providing clues for accurate treatment, and laying the foundation for clinical rational drug use.

Abstract. University of Engineering graduation project is completed successfully "Excellence Engineer" training program as well as a vital innovation ability of graduates reflect and challenging Practice. In this paper, based on "outstanding engineers education training plan" issued by the Ministry of Education focused mission requirements, combined with the author guide in Civil Engineering (bridge class) graduate design experiences, to design a common problem currently teaching graduate design exist to explore, and the corresponding the reform proposals designed to participate in the "outstanding engineers" Training of University plans to build Fostering innovation engineering education personnel to provide reference to further enhance engineering graduates innovation and practical ability.

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