Objective: To analyze the correlation between vitamin A, D, E levels and tumor necrosis factor (TNF-a), interleukin-1 (IL-1), interleukin-10 (IL-10), neutrophil, C-reactive protein (CRP) levels in pediatric community-acquired pneumonia (CAP). Methods: 110 children with CAP and 100 normal children were collected.The concentrations of fat-soluble vitamin A, D, E, the proportion of leukocytes and subtypes, the concentration of CRP, and the concentration of cytokines TNF-a, IL-1, and IL-10 were tested. Differences between vitamin levels and inflammatory factor levels were compared between the two groups.The correlation between vitamin levels and inflammatory factor levels was analyzed in children with CAP. Results: The hemoglobin, leukocyte concentration, neutrophils, monocytes and CRP concentration in the CAP group showed significant differences (P <0.05).The levels of vitamin A, D and E in the CAP group were lower than those in the control group, and the levels of TNF-a and IL-1 were higher than those in the control group, and the difference was statistically significant (P<0.05). IL-10 levels have no significant between 2 groups (P>0.05).The Pearson analysis showed that the vitamin A, D, and E levels were all correlated with the TNF-a, IL-10, and CRP levels (P <0.05). Conclusion: The vitamin A, D, E levels of CAP children were lower than normal children. The content of fat-soluble vitamins are somewhat correlated with the secretion of TNF-a and IL-10 .