A modified concentric glass nebulizer interface for capillary electrophoresis (CE) and inductively coupled plasma mass spectrometry is described. A conductive liquid coaxial sheath in the nebulizer was used as the return ground for the CE capillary. The variable position of the CE capillary in the nebulizer interface made a compromise between separation resolution and signal intensity possible. Negative reservoir pressure was applied to counterbalance nebulizer suction to the CE capillary and restore resolution. Metallothionein and ferritin were evaluated to characterize the interface. Metallothionein isoforms and ferritin were separated and their metal contents identified. Detection limits achieved for 57Fe and 114Cd in ferritin were 184 and 4.0 fg, respectively, for 74 nL injections.Capillary electrophoresis (CE) is applied for the separation of small inorganic1-7 and organic ions,89 small drug molecules,10 peptides,11-14 and proteins.15-18 CE generally offers better resolution and separation efficiency than chromatographic techniques, and the separation is usually faster and requires much less sample (a few nanoliters).Since Smith et al.19 first developed capillary electrophoresismass spectrometry (CE-MS), CE-MS has been extended to almost all kinds of CE techniques.20-23 In most cases, electrospray(1) Jandik, P.;

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