Background Due to the high nursing pressure of patients with cerebral hemorrhage and the general shortage of clinical nurses, nursing support workers often participate in clinical nursing work, but the influence of nursing support workers' participation on the negative emotion, quality of life and life satisfaction of patients with intracerebral hemorrhage is unknown. Methods This quasi-experimental study was conducted with a pretest–posttest design. A total of 181 ICH patients admitted to our hospital from January 2022 to April 2022 were enrolled, including 81 patients receiving conventional care (CG control group) and 80 patients receiving nursing support worker participation (RG research group). All patients were recorded with self-perceived Burden Scale (SPBS), Hamilton Depression Scale (HAMD), Quality of Life Scale (SF-36), Somatic Self rating Scale (SSS), Patient self-care ability assessment scale (Barthel) and Satisfaction with life scale (SWLS) scores. Results Patients with high negative emotion were more willing to participate in clinical nursing work (p < 0.05). Nursing support workers involved in cerebral hemorrhage patients can alleviate negative emotions, improve life quality, improve life satisfaction (p < 0.05). Conclusion The participation of nursing support workers can alleviate the negative emotions of ICH patients, enhance their self-management ability, and improve their life quality.

Background: Intracerebral hemorrhage (ICH) is the deadliest of all stroke disorders. This disease leads to a reduced quality of life for patients, with ICH survivors experiencing functional and cognitive impairment as well as chronic anxiety or depression. However, the exact correlation between patients' quality of life and anxiety symptoms and depressive symptoms remains unclear. It is also unclear whether improvements in patients' quality of life can reduce the degree of abnormal mood. The aim of this study was to investigate the correlation between quality of life, self-burden and mood status in patients with ICH to provide baseline information. Materials and methods: This was a cross-sectional study in which 307 participants were recruited by the Department of Neurosurgery at Southwest Medical University Hospital. Data were collected through semistructured interviews with participants, patient self-assessment questionnaires, and a review of electronic medical records. Results: There were significant correlations among quality of life, participants' self-perceived burden, anxiety symptoms and depressive symptoms (P<0.05). The analysis of the SF-36 scale showed that the physiological health of patients was the main factor affecting anxiety symptoms and depressive symptoms. Conclusion: A decrease in the level of negative emotions in patients was associated with an increase in quality of life and a decrease in the patient's self-perceived burden.

Glioma is the predominant brain malignancy and is correlated with high mortality and severe morbidity. The transcription factor limb‐bud and heart (LBH) has been reported to be involved in the development of several cancers, although its role in glioma development remains elusive. Here, we examined the effect of LBH on glioma progression. The expression of LBH was increased in glioma samples from The Cancer Genome Atlas database, and upregulation of LBH was observed to be correlated with the poor survival of glioma patients. We also report that expression of LBH was elevated in clinical glioma tissues compared to adjacent normal tissues, and was also enhanced in glioma cell lines. LBH promotes proliferation and inhibits cell cycle arrest and apoptosis in glioma cells. In addition, LBH increased the migration and invasion of glioma cells in vitro . Moreover, tumorigenicity analysis revealed that LBH could promote the tumor growth of glioma cells in vivo . In conclusion, our findings suggest that LBH contributes to glioma progression in vitro and in vivo . Our findings provide new insights into the mechanism by which LBH promotes the development of glioma, improving our understanding of the correlation between LBH with cancer. LBH may have potential as a target for glioma therapy.

Background: Due to the high nursing pressure of patients with Cerebral hemorrhage and the general shortage of clinical nurses, nursing support workers often participate in clinical nursing work, but the influence of nursing support workers' participation on the negative emotion, quality of life and life satisfaction of patients with intracerebral hemorrhage is unknown. Methods: A total of 107 ICH patients admitted to our hospital from January 2022 to March 2022 were enrolled, including 60 patients receiving conventional care (CG control group) and 47 patients receiving nursing support worker participation (RG research group). All patients were recorded with self-perceived Burden Scale (SPBS), Hamilton Depression Scale (HAMD), Quality of Life Scale (SF-36), Somatic Self rating Scale (SSS), Patient self-care ability assessment scale（Barthel）and Satisfaction with life scale (SWLS) scores. Results: Patients with high negative emotion were more willing to participate in clinical nursing work (P<0.05). Nursing support workers involved in cerebral hemorrhage patients can alleviate negative emotions, improve life quality, improve nursing satisfaction (P<0.05). Conclusion: The participation of nursing support workers can alleviate the negative emotions of ICH patients, enhance their self-management ability, and improve their life quality.