Herein we report a method for PdII‐catalyzed purine‐directed ortho nitration of 6‐arylpurines via C(sp2)–H activation by using tBuONO/O2 as nitration agent. This procedure is highly efficient and produces a range of 6‐(2‐nitroaryl)‐purine derivatives with good chemoselectivity and functional‐group tolerance. The utility of the method is further illustrated in the synthesis of antibacterial agent.

Abstract. This study focused on electrolysis of refractory malachite green waste water with three-dimensional electrode. In this research, high-purity graphite was used as the cathode, titanium-plating metal mesh as the anode, while coal column, coconut shell granular activated carbon and catalytic Titanium dioxide (TiO 2 ) modified activated carbon as particle electrode, respectively. The electrolytic condition was set as follows: pH=6, the voltage of 8 v, an aeration rate of 20 L/h, an electrolyte concentration of 0.1 mol/L, an electrolysis time of 2 h, and the highest chemical oxygen demand (COD) degradation rate of malachite green was up to 99%. That TiO 2 modified activated carbon served as particle electrode can increase the degradation effect and the current efficiency. Ultraviolet (UV) analysis showed that the structure of malachite green was altered to achieve an effective degradation during the electrolysis process with three-dimensional electrode.

A novel protocol for the construction of highly functionalized indolizine derivatives, that is, 1H-pyrrolo[3,4-b]indolizine-1,3-diones (PIZDOs, 3) from 2-(pyridine-2-yl)acetates and maleimides via a regioselective oxidative [3 + 2] annulation was developed. The cascade oxidative reaction was enabled by heating a mixture of the two substrates in the presence of Ag2CO3 as an oxidant and Cu(OAc)·H2O as a catalyst in chlorobenzene. Consequently, a series of PIZDOs 3 were synthesized with high regioselectivity in moderate yields. This protocol can be used in the synthesis of functionalized PIZDOs via the one-pot oxidative annulation reaction rather than through multistep reactions, which is suitable for both combinatorial and parallel syntheses of PIZDOs.