Ferroptosis, a novel form of regulated cell death, is characterized by imbalance of intracellular iron and redox systems, resulting from overgeneration of toxic lipid peroxidation products. In recent years, the verified crucial role of ferroptosis has been widely concerned in rudimentary pathogenesis and development of various acute and chronic kidney disease (CKD), comprehending the potential patterns of cell death can afford more reliable bases and principles for treatment and prevention of renal disease. In this review, the regulatory mechanisms of ferroptosis were introduced and the important roles of ferroptosis in diverse renal diseases such as acute kidney injury, CKD, and renal fibrosis were outlined to illuminate the potential of restraining ferroptosis in treatment and prevention of kidney disease.

Scarring is caused by excessive medical treatment in the tissue remodeling stage; hence, the need for medication is not constant throughout the stage of burn recovery. In this study, we construct a nano self-adaption release system (Cur-ZIF8-HA) using hyaluronic acid (HA)-modified zeolite-imidazole-frame-8 (ZIF-8) as the nano-vehicle and curcumin (Cur) as the bioactive compound for the treatment of burns. The release of Cur within 48 h in the media of pH 8.5, pH 6.0, and pH 7.4 was 13.94, 54.05, and 20.17%, which could realize antibacterial functions in the inflammation stage, wound healing in the tissue proliferation/formation stage, and prevention of excessive fibroblast development and aberrant extracellular matrix deposition in the remodeling stage. Based on this property, Cur-ZIF8-HA has superior efficacy in healing bacterially infected burn wounds in vivo. This work provides a self-adaption release system with antibacterial wound-healing properties and prevents scarring functional based on the ZIF8-HA nano-vehicle, which opens a new way for the clinical application of curcumin for burn healing.