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Twelve novel metabolites were isolated from Aspergillus gorakhpurensis F07ZB1707. Aspergorakhin A (1) showed selective activities against PTP1B and SHP1 over TCPTP with IC50 values of 0.57, 1.19, and 22.97 μM, respectively.

hexacyclic scaffold (4, 5) were obtained from the fungus Aspergillus deflectus NCC0415. Their structures were identified using comprehensive spectroscopic analysis, single-crystal X-ray diffraction, and electronic circular dichroism calculations. Except for 3, the other compounds, especially the 6/6/6/5/5/6 hexacyclic derivatives (4 and 5), exhibited potent inosine-5′-monophosphate dehydrogenase (IMPDH) inhibitory activities.