This article analyses the spatial spillover effects of infrastructure on regional economic growth by using the panel data of eight cities of Shenyang Economic Zone from 2001 to 2013. The empirical results of this paper indicate: (1) The infrastructure of adjacent regions have positive effects on local economic growth, demonstrating that the spillover effects of infrastructure in Shenyang Economic Zone are positive; (2) if one ignores the spillover effects of infrastructure, one will overestimate the effects of local infrastructure on local economic growth; (3) the effects of local infrastructure on local economic growth are far greater than those of adjacent regions; (4) there is great difference in spillover effects of infrastructure of different cities in the economic zone, which is related to the level of economic development.