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Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthetase (cGAS) and its downstream interferon gene stimulator (STING) act as important immune monitoring media have become a research hotspot. cGAS-STING pathway may play a key role in the occurrence and development of endometriosis by regulating autophagy. The combination of inhibitors targeting cGAS-STING with estrogen or surgery may become a therapeutic approach for endometriosis, and we present a review about the mechanism and physiological function of cGAS-STING pathway, typical autophagy and STING-dependent atypical autophagy, autophagy expression in endometriosis, and a new idea that cGAS-STING may be involved in endometriosis by regulating autophagy.