An efficient and metal-free approach to the construction of diverse functionalized furan derivatives has been developed from ene-yne-ketones and 1,3,5-triazinanes. As an atomeconomical and environment-friendly protocol, the new conditions are suitable for selective C−N and C−O bond formation of a wide range of polysubstituted furans in one pot.

A simple and efficient synthetic strategy from amides, ynals, and sodium sulfinates via a Lewis acid-promoted threecomponent reaction has been reported. Thus, a broad range of various aryl (not alkyl)-substituted oxazoles could be synthesized via the formation of C−N, C−O, and C−S bonds in a one-pot process. In addition, this reaction possesses other unique advantages, such as transition metal-free catalysis, high step economy, good functional group tolerance, and good regioselectivity.