Psoriasis is a chronic, relapsing, inflammatory and proliferative skin disease, mediated by the interaction of multiple factors such as genetic inheritance, immune response abnormalities and environmental factors (e.g. diet, obesity, drugs, smoking, trauma and stress). T helper cell-1 (Th-1) and Th-17-mediated inflammatory pathways are believed to play an essential role in enhancing T cell recruitment to the skin and promoting epidermal hyperproliferation, synergized by various cytokines including interferonγ (IFNγ), TNF, interleukin (IL)-1, IL-6, IL-8, IL-17, IL-22 and vascular endothelial growth factor. 1 Moreover, they synergistically contributed to the characteristic