A radical-mediated
three-component 1,4-sulfonylarylation of 1,3-enynes
with aryl iodides and sulfinate salts using cooperative photoredox/nickel
catalysis is described. This protocol enables the synthesis of tetrasubstituted
sulfonyl-containing allenes under redox-neutral conditions and provides
a versatile 1,3-enyne 1,4-difunctionalization platform for the synthesis
of a diverse range of tetrasubstituted allenes with high chemo- and
regioselectivities, excellent functional group tolerance, and a broad
substrate scope.
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