We synthesized a family of neuromuscular blocking agents (NMB) based on decamethonium, but containing a carborane cluster in the methylene chain between the two quaternary ammonium groups. The carborane cluster isomers o‐NMB, m‐NMB, and p‐NMB were tested in animals for neuromuscular block and compared with agents used clinically: rocuronium and decamethonium. All three isomers caused reversible muscle weakness in mice as determined by grip strength and inverted screen tests, with a potency rank of p‐NMB > rocuronium > decamethonium > m‐NMB > o‐NMB. The mechanism of action of the compounds was determined by using the in vitro rat phrenic nerve hemi‐diaphragm preparation and electrophysiologic measurements in cells. Neostigmine reversed hemi‐diaphragm weakness caused by the three isomers and rocuronium, but not succinylcholine. In electrophysiologic recordings of currents through acetylcholine receptor channels, the carborane compounds did not activate channel activity but did inhibit channel activation by acetylcholine. These results demonstrate that the carborane neuromuscular blocking agents are non‐depolarizers in contrast to the depolarizing action of the parent compound.

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We are in the golden age of AI. Developing AI software for computer games is one of the most exciting trends of today’s day and age. Recently games like Hearthstone Bat- tlegrounds have captivated millions of players due to it’s sophistication, with an infinite number of unique interactions that can occur in the game. In this research, a Monte-Carlo simulation was built to help players achieve higher ranks. This was achieved through a learned simulation which was trained against a top Hearthstone Battleground player’s historic win. In our experiment, we collected 3 data sets from strategic Hearthstone Bat- tleground games. Each data set includes 6 turns of battle phases, 42 minions for battle boards, and 22 minions for Bob’s tavern. The evaluation demonstrated that the AI assis- tant achieved better performance — loosing on average only 9.56% of turns vs 26.26% for the experienced Hearthstone Battleground players, and winning 56% vs 46.91%.

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