Objective: This study was to assess the common withdrawal effects of drugs among addicted population in rehabilitation. Study Design: Cross Sectional Survey. Setting: Different Rehabilitation Centers Located Across the City, Karachi. Period: December 2018 to June 2019. Material & Methods: 400 filled questionnaires were obtained from randomly selected subjects (addicted persons). Results: The results of the study showed, most drugs abused age group is 20-40 year i.e. 71.6%, 13-19 year 18.7%, and 9.7% for population above 40 years of age. Most abused drugs found 34.8%, 26.8%, 9.6% 6.7% for cannabis, tobacco, heroin, and morphine accordingly. n=188 (47%) of patients had adaptive response towards treatment in rehabilitation while n=60 (15%) shows negative and aggressive behaviors. n=60 (15%) patients found guilty of drugs abused while n= 180 45% found it pleasurable. Conclusions: A persistent, safe and evidence-based practices is required in management of drugs abuse among the addicted patients to avoid the risk factors.