This study was designed to assess the effect to apple cider vinegar (ACV) on oxidative stress biomarkers in male and female Wistar rats exposed to chronic restraint stress. Severe and persistent stress elevates reactive oxygen species (ROS) production by metabolic and physiological processes; causing cellular damage. Thirty (30) Adult Wistar rats of both sexes weighing about 150 -200 g were divided into 3 groups each consisting of a male and female subgroup and given the following treatments once a day for 21 days: Normal control group received 0.5 ml distilled water orally, the restraint stress (RS) group was exposed to chronic restraint stress 6 hours daily while the Apple cider vinegar (ACV)-treated group received 4 ml/kg of apple cider vinegar orally in addition to chronic restraint stress 6 hours daily. The rats were sacrificed after the experimental period and blood was collected via cardiac puncture for assessing oxidative stress biomarkers. ACV (4 ml/kg) treatment decreased lipid peroxidation (MDA) and serum catalase (CAT) activity while upregulating endogenous superoxide dismutase (SOD) activity. The findings of this study show that the female Wistar rats are more predisposed to the antioxidant effect of ACV than the males.

Aim: Lipids are referred to as one of the primary targets of reactive oxygen species (ROS). The main sources of oxidative stress in diabetes mellitus comprise various enzymatic pathways, nonenzymatic pathways and mitochondrial pathways. This study was designed to evaluate the effect of theophylline and treatment on lipid peroxidation (serum malondialdehyde concentration) and some

Aims: The study was aimed at comparative evaluation of body weight changes and the serum growth hormone level in female lactating Wistar rats treated with normal saline, metoclopramide olanzapine and risperidone. Study Design: A total of twenty (20) Female Wistar rats weighing between 140-180 g were used for the study. The study was an experimental study carried out on lactating rats. Treatment started three days after parturition. Two atypical antipsychotic drugs were administered orally and their effects compared to that of a normal control group and a positive control.

Aims: This study was designed to evaluate the phytochemical constituents, lipid peroxidation and superoxide dismutase activity of methanol leaf extract of Securidaca longepedunculata (polygalaceae) (MLESL).

Aim:Increase in blood glucose level has been associated with beta cells destruction which is enhanced by lipid peroxidation and hepatocellular damage. The present study was designed to investigate the effect of oral administration of theophylline on Liver enzymes (ALT, AST and ALP) and Liver histology in alloxan-induced diabetic male wistar rats. Study Design: This is an experimental study. Thirty healthy male wistar rats weighing between 160-180 g were grouped into five of six animals each (n=6) following the induction hyperglycaemia using Original Research Article