rogatory title has led people to distrust them. Of course, it is the interpretation that may be spurious. The correlations are on the same footing as any others.

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catalytic site and 39~ from the allosteric site. Oligosaccharides bind in the preferred conformation for a(l-4) linked glycopyrru!osyl polymers in which there is an internal hydrogen bond bebveen the 02 and 03 hydroxyls of adjacent sugars. The major interaction is ;,vi th

No abstract

The crystal and molecular structure of the bisbenzylisoquinoline alkaloid (+)-tubocurarine dibromide methanol solvate, (C37H42N206) 2+ . 2Br-. 4CH3OH, has been determined by Patterson and heavy-atom methods using Cu K~ diffractometer data. The compound crystallizes in the orthorhombic space group P212~21 with a=29.706 (6), b=15-476 (3), c=9.190 (2)A, Z=4. The structure was refined by fullmatrix least-squares methods to R = 0-062 for 2360 observed reflexions. The molecule has one quaternary and one tertiary N atom with a separation of 10"66 A. The molecular structure is fairly open with the phenol ring protruding from the bulk of the molecule. There are several hydrogen bonds involving the two free hydroxyl groups and the tertiary N atom of the tubocurarine molecule, the bromide ions and the solvent molecules. The absolute configuration of the molecule, determined by X-ray anomalous scattering, confirms the configuration assigned earlier by chemical studies.