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A new approach to the analysis of the neuroendocrine system (NES) is suggested. It is based on the fact of structural and metabolic determination of any effect on cell and cell aggregates. The principle of a common communication channel in the NES is formulated and a possible method of its formalization is proposed.

Patients with chronic renal failure often reveal a peculiar "uremic gastropathy" characterized by a decreased secretory activity of the gastric glands. Most of such patients should not be referred to the group of high risk of ulceration. This point is extremely important, when cases are screened for kidney transplantation. Immunomorphological changes occurring in the gastric mucosa provide just one of the possible etiological factors, which also include uremic intoxication and, probably, the intragastric effect of nitrous metabolic products. A long-term (months) therapy by programmed hemodialysis is not, as a rule, accompanied by the development of gastric hyperchlorhydria and hypersecretion.

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