The purposes of the present research are to know the most dominant factor that influences the knowledge about Occupational Safety and Health towards construction workers' behavior; to comprehend the influence of variables of knowledge about Occupational Safety and Health collectively towards construction workers' behavior; the influence of variables of knowledge about Occupational Safety and Health partially towards construction workers' behavior. The research method used in the present research is quantitative method with regression and correlation analysis. Based on the simultaneous hypothesis test analysis of this research, it can be proven that those five variables give influence on the construction workers' behavior. It can be seen from the value of F count which is higher than F table from each variables. Besides seeing from the value of F count, it also can be seen from its significance value. From the research result, its significance value is < 0,05, so it is proven that those five variables give influence on the construction workers' behavior. There are influences between identification and initiation of Occupational Safety and Health, management system of Occupational Safety and Health, personal protective equipment, facilities and infrastructure, and risk of Occupational Safety and Health towards construction workers' behavior. The higher variable of identification and initiation of Occupational Safety and Health, management system of Occupational Safety and Health, personal protective equipment, facilities, and risk of Occupational Safety and Health are: the better behavior of construction workers will be. Based on the analysis of simultaneous hypothesis test, it can be proven that those five variables give influence toward the construction workers' behavior.