Introduction: Coronavirus Disease of 2019 (COVID-19) has been deemed as one of the biggest global health crisis. The pandemic has caused a landslide in governance, economics, health care systems, and the daily lifestyle of man for the past 2 years. One of the chief weapons installed by various governments worldwide was the rapid development of an efficient vaccine to combat the disease. This study aims to identify the awareness of COVID 19 and seeks to find the challenges faced by the community in vaccination. This study hypothesized the presence of a multifaceted issue among the transgender populations' hesitance to vaccination. The results from the study could be exploited by the policy makers of the government to provide policies that best alleviate the hesitance among the transgender population. Material and Methods: This study is a cross sectional questionnaire based study. A total of 121 transgender people above the age of 18 years who were voluntarily willing for the study were included in the study, while excluding the male and female participants and those transgender participants who were unwilling for the study. Results and Discussion: A 100% response regarding COVID-19 awareness from the 121 participants showed exemplary reach to the population. With 76% of individuals being vaccinated, the acceptance of the vaccine and reach of the vaccine was high. COVID-19 awareness has reached the people from all walks of life. With little tweaks to the current policies, India could achieve absolute vaccination against the pandemic.

The study aimed to evaluate the prevalence of oral leukoplakia and to assess the risk of developing oral leukoplakia in patients with tobacco-related habits among the populations of Chengalpattu district, Tamil Nadu, India. Materials and MethodsIncidence and prevalence of oral leukoplakia differ among different populations in India due to cultural and demographic diversities. The results obtained from this study can be used as a reference in future research and policy-making for tobacco control. Data for this study were manually ascertained from the

Oral cancer poses a serious health challenge to the nations worldwide. India, among all the nations reported, has the largest number of oral cancer cases, which accounts for one-third of the entire population of oral cancer globally. As oral cancer is well-known for delayed diagnosis until an advanced stage, poor outcomes, and a lack of specific biomarkers for the disease and high-budget therapeutic alternatives.Stem cell derivative exosomes gained significant attention as therapeutic agents and diagnostic biomarkers in cancer biology. It's a type of extracellular vesicle, which are lipid-bilayer-enclosed vesicles of endosomal origin. They are nanosized membrane vesicles that are capable of self-renewal, unlimited proliferation, and multi-directional differential potential. Thus, they act salient in the occurrence and development of tumors. Exosomal micro-RNAs (miRNAs) are functionally related to the advancement of cancer, metastasis, and the aggressive nature of tumors with high recurrence rates.It has also been highlighted that exosomes have the potential to serve as diagnostic markers. A quick, easy, high-clarity, and confined rehabilitation method is the basic specification for large-scale usage of exosomes. The constitution of the composite transporters of exosomes is easily available by sampling biological fluids (liquid biopsies) from samples such as saliva. A liquid biopsy based on exosomes focuses on their probable usage in cancer patients' diagnosis and the determination of the outcome or course of the disease. This review explores the therapeutic prospect of stem cell-derived exosomes as intending to offer new ideas for clinical management and institute a new era of therapeutic agents for oral cancer.