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By selection of certain strains of the ergot fungus found on Pennisetum typhoideum Rich. (a tropical millet) and modifying the substrate we succeeded in increasing the alkaloid yield in saprophytic cultures up to 1000–1500 mg alkaloids per liter of culture filtrate and increasing the alkaloid content of the mycelium to 1% of its dry weight.

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Aus den Sklerotien eines auf der afrikanischen Kolbenhirse Pennisetum typhoideum Rich. gefundenen Mutterkornpilzes konnte das Alkaloid Agroclavin isoliert und identifiziert werden. Aus den Sklerotien wurden Pilzstämme isoliert, welche die Fähigkeit besitzen, in saprophytischer Kultur in vitro Alkaloide zu bilden. Aus Kulturfiltraten und aus Mycelien konnten die beiden bereits bekannten Alkaloide Agroclavin und Elymoclavin, sowie ein neues Alkaloid mit der Bruttoformel C16H18O2N2, für das wir die Bezeichnung Penniclavin vorschlagen, isoliert und charakterisiert werden.

Many parents are anxious because of the insufficient arch of the feet of their children. A true congenital deformity (congenital vertical talus) is extremely rare. In children the arch is physiologically flattened with a hypervalgus of the hindfoot. Those feet do not need treatment. If there is no medial recess in the footprint in a child over 3 years of age, then we are talking about a flexible flatfoot. When the load of the foot is more pronounced at the medial rather than at the lateral side, operative treatment can be indicated, such as a lengthening osteotomy of the calcaneum. If the flatfoot is rigid, the reason for it is usually a tarsal coalition. Operative transection of the osseous bridge with fat interposition can solve the problem. Flatfeet may also occur in neuromuscular diseases. Depending on the severity of the deformity, splints can be effective, or--in the more severe cases--operative treatment such as a triple arthodesis can be indicated.