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Background: MRCC is a devastating disease with poor long-term outcomes. The addition of bevacizumab (BEV) to chemotherapy (CT) significantly improved overall survival (OS) in MRCC patients (pts). Aim: to characterize clinico-pathologic features associated with CR and its impact on outcome of MRCC pts. Methods: Single-institution prospective series of MRCC pts who were treated with 1 st line CT between 2005 and 2018. CR was defined by Response Evaluation Criteria in Solid Tumors (RECIST v1). Prognostic and predictive value of "Moore criteria" was evaluated.Results: 98 pts (61% squamous; 29% adenocarcinoma; 8% others) with median age of 49 years (28-77) were investigated. 57 pts (58%) had prior CT-radiation; 73 pts (75%) had recurrent/persistent disease (39 pts > 12 months (m) disease free interval) and 23 pts (24%) were stage IVb at diagnosis (47% visceral involvement). Moore risk distribution: 9 high, 53 medium, 9 low risk. 70 pts (72%) platinum-based-CT (PCT) (46% Cisplatin; 26% Carboplatin); 24 pts (25%) received CT þ BEV. After a median followup of 21.2 m, overall response rate (RR) was 59%, median PFS was 7 m (CI95% 6-9) and median OS 14 m (CI95% 11-24). Moore criteria correlated with prognosis (highrisk pts had significantly worse OS, HR ¼ 25, p < 0.001). Higher RR was observed among low and intermediate risk pts (77% and 54%) as compared to high (11%, p < 0.001). CRs occurred in 21/94 (22%) evaluable pts (BEV group 5/23; non-BEV 16/ 71, p ¼ 1). Factors associated with CR in univariate analysis: no visceral involvement (OR ¼ 1.54, p < 0.01), no prior CT (OR ¼ 1.85, p ¼ 0.04) and Moore criteria low/intermediate (vs. high, OR ¼ 2.36, p ¼ <0.01). Median time to CR and median duration of CR were 4.6 m (4.1 -5.3) and 7.4 m (3.6-NR), respectively. CR significantly impacted on PFS (14.6 m vs 6.5 m non-CR, p < 0.001) and OS (NR vs 11 m non-CR, p < 0.001). Nine pts discontinued treatment due to toxicity (1 pt had vesico-vaginal fistula related to BEV). Conclusions: CR is a meaningful surrogate marker for improved PFS and OS in MRCC pts treated with 1 st line CT. In our series, visceral involvement, prior CT and Moore criteria were identified as predictive markers for CR. Legal entity responsible for the study: A. Oaknin.

Pendahuluan: Asma merupakan penyakit saluran pernapasan dengan angka prevalensi tinggi di Indonesia dan Provinsi Bali menduduki urutan ke-enam dengan prevalensi asma tertinggi di Indonesia. Penderita asma dianjurkan untuk melakukan latihan fisik untuk meningkatkan kebugaran serta meringankan dan mengurangi frekuensi kekambuhan. Zumba dan Yoga merupakan jenis latihan fisik yang memberikan banyak manfaat terutama pada fungsi paru. Tujuan:  Membuktikan adanya perbedaan nilai APE pada wanita usia produktif penderita asma yang mengikuti latihan Zumba dan Yoga. Metode: Penelitian ini merupakan penelitian observasional analitik dengan pendekatan potong lintang yang melibatkan 18 wanita usia produktif penderita asma derajat intermiten atau persisten ringan pada kelompok Zumba dan Yoga. Sampel dipilih dengan teknik purposive sampling yang dilakukan pada tujuh studio senam Zumba dan Yoga di Denpasar selama bulan Juni – Oktober 2019. Data diperoleh dengan lembar pengumpulan data dan pengukuran APE menggunakan Peak Flow Meter. Data dianalisis dengan uji Parametrik T-Tidak Berpasangan untuk membandingkan nilai APE pada wanita penderita asma yang mengikuti latihan Zumba dan Yoga. Hasil:  Pada wanita usia produktif penderita asma yang mengikuti latihan Zumba memiliki rata-rata nilai APE sebesar 431,11 L/menit, sedangkan penderita asma yang mengikuti latihan Yoga 398,89 L/menit, dengan p=0,04 (p<0,05) yang menunjukkan bahwa terdapat perbedaan bermakna pada nilai APE wanita usia produktif penderita asma yang mengikuti latihan Zumba dan Yoga.