No abstract

%'he irnfluerlce of perfusion pressure on vcntricuhr hbrillatlo~l was studied in the isolated rabbit heart. Su~dderi drops ill perfusion pressure inhibit veritricular fihrillatir~n in n few minutes, whereas a slow dwrenstt. of the pressure tloes not stop the fit)rilI;ltion, but nevertheless reduces the ventricular liri~lg rate. High perfusion pressures facilitate the inductio~m of fil~rillation; low pressures delay the proeiuction of arrl-iythmias and shorten their duration. I t is postulated that this effect of presure is primarily ~i~echa~lical and not strictly depe~~tlent upon cllanges in the corclriary flow or in the ~rlyocarclial te~riperature.

Although the drug has been studied in hospitalized patients, it has yet to be tested with outpatients. This is a preliminary study