Synthesis and Microbial Activity of New Thiazolyl-1,4-benzothiazines. -Some new thiazolyl-1,4-benzothiazines (VI) are synthesized via oxidative cyclocondensation of diones (IV) with 2-aminobenzenethiol (V) and evaluated for their antibacterial and antifungal activity in vitro. -(DENGLE, R. V.; INGLE, R. D.; BONDGE, S. P.; MANE, R. A.; Indian J. Chem., Sect. B: Org.

Block copolymers consist of two or more segments of polymer chains in a typical arrangement through connected covalent bonds. Biodegradable block copolymers have emerged as useful carriers for controlled drug release, tissue engineering, and other biomedical applications due to their ability to form colloidal systems and tunable properties. This review focuses on recent advancements in the synthesis, characterization, and biomedical applications of biodegradable block copolymers.

A highly efficient three-component one step system for the synthesis of 2-amino-4H-chromens is developed. Excellent yields were obtained simply by mixing malononitrile, aromatic aldehyde and α-napthol in lemon juice as a catalyst of natural origin and solvent, avoiding using hazardous organic solvents. The main advantages of this method are its green method character, short reaction time and simple workup procedures and the lack of using any metal containing catalysts. * Corresponding Authors

Although chemical structural modification of naphthalimides is widely employed for the purpose of sensing explosives, the effects of such modification have been little explored. Herein, we report the design and synthesis of a new naphthalimide-benzothiazole conjugate (1) and its ability to sense various nitrophenols by means of its colorimetric and fluorescent characteristics. Under long-range UV light (365 nm), 1 displayed a color change of its solution from bluish to colorless only upon addition of 2,4,6-trinitrophenol (TNP). Photoluminescence spectroscopy showed quantitative fluorescence quenching by TNP of the emission peaks of 1 at 398 nm and 418 nm due to donor–acceptor electron transfer. The interaction of 1 with TNP was via a cooperative, non-covalent hydrogen-bonding interaction. Receptor 1 exhibited high sensitivity and selectivity towards TNP over various aromatic nitro analytes. The binding constant (K) and Stern–Volmer constant (Ksv) between 1 and TNP were found to be 5.332 × 10−5 M and 2.271 × 106 M−1, respectively. Furthermore, the limit of detection was calculated and found to be as low as 1.613 × 10−10 M.

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