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The concept of Industry 4.0 corresponds to a new way of organizing the production of goods, taking smarter decisions based on environmental variables and optimizing available resources. However, there is still a journey to carry out the implementation of this concept with current technologies. To make this transformation of the industry, it is necessary to characterize the Industry 4.0 concept, adopt a strategic thinking, and acquire skills, aptitudes, and attitudes. Enterprise reference models can help in orchestrating the change, however, the relationship between existing reference models and Industry 4.0 needs further clarification. Thus, this paper proposes a framework that links a reference model with the Industry 4.0 concept. Furthermore, a tool for the instantiation of the framework is proposed to provide practical approach. And the results of implementing the proposed framework are presented in a case study.