The existence of the hypothesized concept of medication acceptance was confirmed. The ACCEPT© questionnaire will allow assessment of the acceptance of a wide range of long-term medications based on patient experience. Further study will examine how well this measure predicts and explains adherence to these medications.

The results of this model, under the assumptions described in the paper, suggest that in women aged 70-80 years, screening all women with dual-energy X-ray absorptiometry (DXA) would be more effective than no screening or screening only women with at least one risk factor. Cost-effectiveness studies based on decision-analysis trees maybe useful tools for helping decision makers, and further models based on different assumptions should be performed to improve the level of evidence on cost-effectiveness ratios of the usual screening strategies for osteoporosis.

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A335 were asked to complete Accept and MMAS-4 questionnaires at Month 1, 3 and 6 after having given their informed consent. The structure was explored through PCA, and confirmed with multi-trait analysis. Internal consistency reliability of dimensions was assessed through Cronbach's alpha. Scale-scale correlations were calculated. Results: After reduction, Accept was made of 25 items organised in 1 overall Acceptance score and 6 domain-specific scores (efficacy, tolerance, convenience, constraints, treatment duration, multiple medication). Cronbach's alpha was 0,85 for overall Acceptance score, which met convergent and divergent validity criteria (both 100%). The domain-specific scores showed satisfactory to good results (Cronbach's alpha ranging from 0,67-0,87, convegrent validity ranging from 63% to 100%, and divergent validity ranging from 33%-100%). Scale-scale correlations ranged from 0.02 to 0.58, confirming the multi-dimensional nature of the questionnaire. The good properties of Accept were stable over time. ConClusions: Accept is a brief, comprehensive, generic questionnaire focused on Acceptance. Initial validation in a population of patients with a wide range of long-term treatment showed promising results and confirmed the position of Acceptance. Further, disease-specific, large prospective study are needed to assess the ability of Accept to predict persistence to treatment.