Background: Manikkadai-Nool (MK) is an ancient Siddha treatise of Anthropometric based predictions very much acclaimed for its diagnostic value in clinical practice. A well-set protocol is lacking for the methodology, limiting its expected outcome of predictive values. Moreover, the systematic approach of case reporting pertaining to its diagnostic accuracy studies (DAS) is showing many pitfalls. This purposes the induction of guidelines particular to MK that covers the entire aspects of case reporting. Materials and Methods: Available case reporting guidelines for Diagnostic studies (STARD guidelines) were overlooked to develop the core elements for DAS with 9 sections including 24 items. Discussion: The enlisted 24 items of Siddha Anthropometric Tool (SAT) guidelines have been depicted with examples that enable physicians and researchers to accomplish clinical reporting based on MK with much ease and accuracy. The guidelines may help peer reviewers for evaluating the concerning studies. Conclusion: SAT guidelines improve the quality of studies pertaining to MK that imprints the lead for further scientific acceptance. Further periodical up-gradation is warranted.

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Introduction: Hydro distillation in Siddha medicine is the technique of extracting valuable principles from a pre-processed raw drug through the traditional process of distillation under a controlled temperature setting. Thiribhaladi Dravagam (TD) is one of the polyherbal distillate formulation stated in the Tamil medical text specified for phlegmatic affections. The drug was subjected to GC-MS studies to screen its bioactive sketch. Methods: Two sets of raw drug samples from different locations were collected. The raw drugs were purified and pre-processed as per the classical literature and distilled in a traditional apparatus. Two distillate samples (TD 1 & TD 2) were prepared from the set of ingredients and were screened for its constituents. Results: The Gas chromatogram of TD 1 revealed 4 prominent peaks with retention time ranging from 4.84 to 8.27. TD 2 reported 8 prominent peaks with retention time ranging from 3.35 to 7.88.  The study testified the presence of active volatile metabolites like aldehydes and oxygenated monoterpenes like citral and borneol, monocyclic alcoholic compounds like terpineol and organic acids like caprylic acid from both the samples. TD 2 reported more pharmacologically valuable lead molecules than TD 1, which may be due to the variation in diversity of the two sets of raw drug samples. Conclusion: The bio constituents of TD was found to be pharmacologically significant from the review of various reputed research works supporting the traditional claim on its role in  the respiratory system and for maintaining good health. Through the review of Thiribhaladi Dravagam and its analytical part performed through GC-MS, the medical applications of TD in multiple clinical associations and as a perfect health promoter has been justified for promoting its traditional value.

The distillate formulations in siddha medicine called theeneer is the aqueous dosage form obtained by the effective distillation of herbal parts especially by using traditional apparatus. Terminalia chebula is an exquisite raw drug used in almost all type of siddha drug formulations. The herb is considered as a rejuvenator with its acclaimed antioxidant property. The usage of the drug is prevalent in many distillate preparations. To prepare the distillate from Terminalia chebula and to analyze the bio active compounds for determining its effectiveness as a rejuvenator and antioxidant supplement. The raw drug kadukkai (Terminalia chebula) was processed and distilled with reference to siddha texts and the distillate sample was analyzed through GC-MS. The prepared kadukkai theeneer was colorless with slight typical odor and taste. A total of 12 compounds were spotted in the sample distillate belonging to class of fatty acid esters and volatile siloxanes. Few of the compounds like hexadecanoic acid and pentadecanoic acid has reputed antioxidant property, other still unreported but can be ascertained as they belong to the same class of fatty acids. The study puts forward the possibility of using kadukkai theeneer as a rejuvenator supplement.

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