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The pathobiological role of free radicals was demonstrated in hyperlipidaemia and in steatotic liver as well as in the immune response of lymphocytes and monocytes. Hyperlipidaemia has a suppressive effect on cellular immune responses, inhibits the mitogen induced lymphoblast transformation, diminishes the tumour necrosis factor alpha (TNF-a) production of spleen macrophages and enhances spontaneous interleukin 1 (IL-1) activity. A freeze dried extract of Semperuiuum tectorum has antioxidant, free radical scavenger and membrane stabilizing effects. The measured serum parameters were changed favourably after Sempetviuum tectorum extract treatment. The beneficial effect of Semperuiuum tectorum extract was also observed on the Con A stimulated blast transformation of splenocytes, on the lipopolysaccharide (LPS) triggered TNF-a activity and on the spontaneous IL-1 activity of spleen macrophages of hyperlipidaemic rats. The natural scavenger capacity was increased by treatment, initiating restoration of liver function.

Interleukin-1 and tumor necrosis factor-alpha activity by E. coli lipopolysaccharide-triggered monocytes were studied in patients with chronic alcoholic liver disease. Monocytes from cirrhotic patients were shown to have a significant reduction in IL-I and TNF-a activity, compared with that from age-and sex-matched healthy controls. These findings indicate further immunoregulatory disturbances concerning alcoholic liver cirrhosis.

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