For the first time, studies have been conducted to study the features of the heart rate response of laboratory animals exposed to various modes of motor activity when administered β, α1 and α2-adrenostimulants. It was found that in animal’s subject to a regime of limited motor activity, i.e. hypokinesia, the heart rate response to the introduction of β and α1-adreno stimulators remains at a high level. It was revealed that the regime of systematic muscle training significantly contributes to the reduction of this reaction. It was found that in the process of systematic muscle training of animals, there is also a significant decrease in the heart rate response to the introduction of an α2-adrenostimulator. The hypokinesia mode keeps this reaction at a high level.