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Infected wounds and burns are frequently treated with drug preparations in the form of ointments on hydrophilic bases, which markedly increase and accelerate the therapeutic effect of the drugs.In this work we have studied the ability of alkaline protease entering into a hydrophilic polymer base to form ointment compositions and the possibility of including alkaline protease into these polymer-based compositions jointly with polymyxin B, decamethoxine, dioxidine, trimecaine, or urea. EXPERIMENTAL PARTExperiments were performed with alkaline pmtease from Bacillus subtilis 72 (a proteolytic enzyme with broad substrate specificity), protease C from Aeremonium chrysogenum, terrilytin from Aspergillus terricola, and asperase from Asperg771us oryzae.

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