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A series of aryl polyfluoro 1,3-diketones were examined for systemic ectoparasiticidal activity in cattle. The compounds demonstrated efficacy against several economically important species of insects and acarina. At dosages of 5 mg/kg X1 or 0.35 mg/kg per day intraruminally, activity was observed against blowfly larvae (Phormia regina), adult stable fly (Stomoxys calcitrans), and lone star tick (Amblyomma americanum). In vivo activity was not directly related to in vitro activity, showing a stronger dependence on perfluoroalkyl-chain length and aryl-group substitution.

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