A B S T R A C T Total secretory IgA and specific antiantigen E (AgE) antibodies (ab) Blocking activity in the nasal washings was measured by inhibition of histamine release and was found to correlate directly (ra + 0.85, P <0.001) with binding activity for AgE. Some washings from normal persons caused slight inhibition of histamine release but others caused enhancement. Nasal washings were fractionated by passage over Sephadex G-200.
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