Aim: To assess if probiotics alter the adherence of candida species onto the denture base material made with Polymethylmethaacrylate(PMMA). Materials and Methods: Sample number of 10 per denture base resin with Sample dimensions of length 10 mm × 10 mm and width 2 mm. Test Group: PMMA samples coated with probiotics at varying concentrations dipped in saliva Containing candida species. Control Group: PMMA samples in saliva containing candidal species without probiotics. Results: Significant difference of candida cell count on PMMA was evident before and after giving probiotic. On the heat cure denture base materials, there was a significant decrease in Candidal cell counts when the probiotic concentrations (2.5, 5, 10, 15 and 20 µg/ml) increased.

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