A synthetic route with two consecutive coordination chemistry steps on a solid support affords tris-heteroleptic ruthenium(II) polypyridyl complexes with high purity and in good yields. As an application we report the identification of a nanomolar acetylcholinesterase inhibitor from a small ruthenium complex library synthesized on Lanterns.

Efficacy and safety of coaxial transthoracic fine-needle biopsy were evaluated in 54 patients with a history of malignant lymphoma and new chest lesions. Twenty-one patients had recurrent lymphoma. Correct diagnosis was made in 17 of the 21 patients (81%) after one biopsy. The sensitivity increased to 95% with repeat needle biopsy in three patients. Immunophenotyping (determining phenotype by means of immunologic examination) was essential for a definitive diagnosis of lymphoma in three patients. Non-lymphomatous malignancies were correctly diagnosed in 14 patients. An infectious organism was identified in 11 of 19 patients (58%) with benign lesions. Pneumothorax occurred in eight patients (15%), necessitating placement of a chest tube in two (4%). Mild hemoptysis was observed in four patients (7%). The authors conclude that coaxial transthoracic fine-needle biopsy in patients with a history of lymphoma is safe and accurate. The use of large cutting needles or surgical biopsy can be restricted to patients with false-negative findings at percutaneous biopsy and to patients in whom histologic transformation of lymphoma is suspected.

Most processes involving the scrotum are infectious or inflammatory in nature. Testicular tumors are relatively uncommon, making up about 1% of all cancers in men. Lymphoma is the most common scrotal tumor found in men over 60 years old. The testicle is the usual site of involvement with spread beyond the tunica albuginea into the extratesticular compartment noted in only 10% of cases.l In this report we describe the sonographic findings of a predominantly extra testicular intrascrotal mass arising in an HIVpositive patient mimicking a scrotal abscess in both clinical symptoms and ultrasonographic appearance but proved to be a non-Hodgkin's lymphoma. CASE REPORTA 68 year old HlV-positive black man was admitted for evaluation of jaundice. The history revealed anorexia, nau· sea, vomiting, and weight loss. On physical examination the patient was found to be afebrile and icteric. The liver was mildly enlarged and a few small lymph nodes were palpable in the axilla. The scrotum and prostate were ABBREVIATIONS HIV, Human immunodeficiency virus; CT, Computed tomography; AIDS, Acquired immunodeficiency syndrome