A histopathologically-verified, clinically typical case of Creutzfeldt-Jakob disease (CJD) is described in a 19 year-old girl. Only 3 previous cases of CJD have been reported in adolescents, and one of these was iatrogenically transmitted, while another was familial. Epidemiologic investigation of the present case excluded a familial component, and provided no evidence for iatrogenic or natural case-to-case transmission, or of other environmental sources of viral contamination. Young patients such as this one serve to emphasize the obscurity that still surrounds the epidemiology of CJD, and invite serious reconsideration of the possibilities of transmission by undetected virus carriers, or of the agent as a natural resident of human cells, replication of which might be triggered by non-infective (e.g., traumatic or mutational) environmental events.

No abstract

C~R A HETENYI11. Apres section de la moelle epiniere au niveau des segments dorsaux 11 et 12, la ligature de l'artere de la moelle osseuse ne produit pas d'drythrocytose. 12.Les experiences sur des chiens a circulation croisee montrent que le chien m&me 21 moelle kpinibre sectionnee r6agit par l'erythrocytose au facteur qui se libbre de la moelle osseuse hypoxique de l'animal a moelle 6piniere intacte. Si au contraire nous avons ligature l'artbre de la moelle osseuse du chien a moelle dpinibre sectionnee, l'drythrocytose ne s'est pas manifestke chez le chien a moelle epinibre intacte. On peut en deduire que, dans la formation de la substance provenant de la moelle osseuse hypoxique et provoquant 1'6rythrocytose, un processus rdflexe de la moelle epiniere de caractere proprioceptif intervient egalement.Phenacetylurea deserves to take its place in the treatment of epilepsy. Its action is exerted in different degrees in all types of epilepsy, grand ma1,petit ma1 and psychomotorial mal. An electrical amelioration does not always superpose itself to the clinical efficacity; this disassociation is perhaps explained by the insufficiency of doses employed in certain cases and the lack of a sufficient recoil. The indications of phenacetylurea rest on data still too fragmentary to be codified. The medicine could not without exaggeration be substituted for drugs whose efficacity in the matter of epilepsy is already proved. Nevertheless the crises of grand ma1 rebellious to the classical anticonvulsants, the petit mal, treatment of which by derivatives of oxazolidine-dione is followed by signs of intolerance and above all hematologic alterations, appear t o justify treatment with phenacetylurea. The associations of grand ma1 and petit mal, forms so difficult to treat in practise, will certainly give one indication of the choice of method. The efficacity of phenacetylurea, noticed by anglo-saxon authors, in the treatment of paroxistic manifestations of psychomotorial epilepsyand of which we have no experienceshould be added to the list of actions of this medicine.