The POBF increases throughout gestation. During pregnancy there is an increase in estrogen which induces endothelial-dependent vasodilatation in several tissues. The estrogen changes may influence POBF.
However these data support the hypothesis that vascular factors can play an important role in the pathogenesis of o p tic nerve disease in NPG. On the contrary, in the same NPG patients, the reduction of peripheral plasma and aqueous humour cGMP levels suggests that a disorder of NO regulation processes might affect both the blood supply to the optic nerve and the aqueous humour outflow and then significantly participate in the onset and progression of glaucomatous disease.
References
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