Analysis of the results of medical examination of pregnant sheep 30...15...5 days before the expected term of lambing showed that in the urine of 12.11% of ewes, the concentration of ketone bodies in the blood plasma was 1.43 times higher than the physiological norm. In addition, there is a tendency to decrease the buffer bases to 18.41±1.53 mmol/l, as well as the glucose content below 2.12 ± 0.12 mmol/l. At the same time, the ratio of VN/ ACAS is up to 1.47 ± 0.12 mmol / L. It was found that the albumin fraction of proteins decreased by 1.51 times. Edema in the abdominal wall and underbelly, 9.5% lack of reaction to external stimuli, 15.0% decreased appetite, 10.0% jaundice of mucous membranes and 9.0% of sheep had a comatose state were found in 15.0% of animals. In a clinical study in sheep with eclampsia, hypertension over 136.1 mmHg and the presence of protein in urine over 3.2 g/l were recorded. These symptoms indicated classic signs of eclampsia, which occurred depending on the condition of sick animals in atypical and typical forms of manifestation. In animals with typical clinical signs of eclampsia, an increase in the level of diene conjugates was found to be 1.87 times, and the concentration of ketodiene intermediates and conjugated trienes was 1.75 times, the concentration of stable nitric oxide metabolites was 38.0%, and the vitamin E content decreased by 13.1%. At the same time, there was a 20.46% increase in the concentration of double bonds in the atypical form of eclampsia. In the blood plasma of patients with eclampsia of pregnant ewes, the activity of superoxide dismutase (1,736±0.37 units) is lower than in the comparison group (2,146±0.56 mmol/l). The obtained material of this work should be taken into account in the future when studying the problem of complicated pregnancy in the last stages of gestation in sheep and when developing therapeutic and preventive measures to ensure the long-term functioning of the reproductive potential and obtaining a viable newborn offspring.

The clinical picture of the manifestation of various forms of eclampsia in pregnant ewes has been established, signs of a mild form of eclampsia in pregnant ewes are depression of the central nervous system. During the movements, the sheep staggered, the gait was uncertain. Quite often, there was a frozen pose, the animals stood with their necks outstretched and their heads held high. Characteristic signs of severe form are fibrillary twitching of the muscles of the ears, neck, and around the mouth. During the whole time, the animal was in a state of catalepsy. The sheep was lying on its side 8... 10 hours before its death, its limbs and neck were stretched out; it tried to throw its head back. Nervous excitement turned into a comatose state. Laboratory blood tests have established an increase in the level of ketone bodies above physiological limits by 2.3 times and their fractions — AcAs and HH, respectively, by 5.9 times and 1.5 times, a decrease in buffer bases to 18.41 ± 1.53 mmol/l, glucose concentration to 2.25±0.16 mmol/l, as well as the HH/AcAs coefficient to 1.53. The conducted ELISA of blood serum allowed us to obtain information about the levels of FSH, LH, etch radial values in the group of sheep with eclampsia and the control group, which significantly differed from each other (p<0.05). The content of cortisol (21.4±3.47 ng/ml), as well as progesterone (11.2± 4.31 ng/ml) remains quite significant, which does not allow for metabolic processes. In the blood of ewes with eclampsia, an increase in the concentration of ketodiene intermediates and conjugated trines was found to be 1.75 times, and the content of manol dialdehyde was 1.125±0.34 mmol/l. An integrated approach to the examination of pregnant ewes in the framework of obstetric medical examination increases the diagnostic effectiveness of eclampsia detection by 24.3% compared to traditional research methods. The diagnostic sensitivity was 75.8%, the specificity of the test was 96.2%, the prognostic value of a positive result was 94.5%, and the prognostic value of a negative result was 83.9%.>˂0.05). The content of cortisol (21.4±3.47 ng/ml), as well as progesterone (11.2± 4.31 ng/ml) remains quite significant, which does not allow for metabolic processes. In the blood of ewes with eclampsia, an increase in the concentration of ketodiene intermediates and conjugated trines was found to be 1.75 times, and the content of manol dialdehyde was 1.125±0.34 mmol/l. An integrated approach to the examination of pregnant ewes in the framework of obstetric medical examination increases the diagnostic effectiveness of eclampsia detection by 24.3% compared to traditional research methods. The diagnostic sensitivity was 75.8%, the specificity of the test was 96.2%, the prognostic value of a positive result was 94.5%, and the prognostic value of a negative result was 83.9%.