During pregnancy the characteristic increase in the thyroxine-binding capacity of the circulating globulin, TBG (1-3), is associated with a retarded rate of thyroxine turnover (4) and an increase in the concentration of hormonal iodine (PBI) in the plasma (1-4). These alterations in iodine metabolism have not been found in women with choriocarcinomas who excrete large quantities of chorionic gonadotropin (5), but do occur in nonpregnant individuals given large quantities of estrogens (6-8). It has been concluded, therefore, that during pregnancy these phenomena result from systemic effects of placental estrogens. Moreover, the sera of aborting women often fail to show the characteristic increase in serum PBI (9) and in thyroxine-binding by TBG (2).In the past, attempts have been made to use the concentration of PBI as an indicator of fetal viability (9, 10); however, as appears to be true of studies of urinary or plasma chorionic gonadotropin determinations, pregnandiol and estrogen levels, and vaginal smears (11-15), the PBI has not proved satisfactory for routine use. It appeared possible, however, that assessment of TBG might prove of value as an indicator of placental function. For that reason a technique was developed for rapidly estimating serum thyroxinebinding, and its value in predicting the outcome *