Platelet-rich plasma (PRP), a recently developed autologous cellular therapy, has the potential to perform new functions in an array of regenerative pharmacological treatment plans. Platelet growth factors (PGFs) promote the three stages of the wound recovery and repair cascade, which is the cornerstone of PRP therapy (inflammation, proliferation, remodelling). In vitro, in vivo, and animal experiments were used to test a wide range of PRP formulations. Yet, because it is difficult to apply the findings and technique recommendations from non-clinical studies to human clinical treatment protocols, recommendations from in vitro and animal research frequently result in various clinical manifestations. In this study, we addressed recent advancements in PRP production and composition, applications in periodontics, and PRP mechanisms relating to tissue inflammation and angiogenesis.