Annotation. Received the large set of factors influencing the success of the results and duration of patients treatment with periodontal disease, as well as different levels of correlation of these factors it is advisable to study the use of adjuvant antibiotic therapy in the patients treatment with periodontal disease, which became the purpose of our work. To test the effectiveness of adjuvant antibiotic therapy in the complex treatment of periodontal pathology from the primary study category of patients, four groups were formed a total numbering of 240 people: the group of antibiotics without determining antibiotic sensitivity, the group of antibiotics according to rapid diagnosis, the group of antibiotics according to detailed analysis group of amoxiclav and ciprofloxacin. Mathematical and statistical data processing was performed using the application software STATISTICA 6.0. According to a meta-analysis of the effectiveness of antimicrobial and subantimicrobial antibiotic therapy as an adjuvant approach to the treatment of periodontal disease, it was found that the use of broad-spectrum agents and targeted antianaerobic drugs contributed to a more pronounced improvement in clinical attachment and reduced depth levels. Thus, antibacterial support of the active phase of the periodontal therapy protocol contributes to the clinically significant reduction of the main symptoms associated with the influence of relevant associations of periodontal pathogens, reducing the actual number of such and imbalance of their quantitative ratios in the biofilm structure as a specific factor. Reducing the volume of repeated iatrogenic surgical and conservative interventions due to the early use of antibacterial agents also contributes to the increase in cost-effectiveness, as fewer total manipulations contribute to achieving the appropriate target effect.