Carbon Capture and Storage (CCS) is a recently discussed new technology, aimed at allowing an ongoing use of fossil fuels while preventing the produced CO 2 to be released to the atmosphere. CSS can be modeled with two components (water and CO 2 ) in two phases (liquid and CO 2 ). To simulate the process, a multiphase flow equation with equilibrium phase exchange is used. One of the big problems arising in two-phase twocomponent flow simulations is the disappearance of the nonwetting phase, which leads to a degeneration of the equations satisfied by the saturation. A standard choice of primary variables, which is the pressure of one phase and the saturation of the other phase, cannot be applied here.We developed a new approach using the pressure of the nonwetting phase and the capillary pressure as primary variables. One important advantage of this approach is the fact that we have only one set of primary variables that can be used for the biphasic as well as the monophasic case. We implemented this new choice of primary variables in the DUNE simulation framework and present numerical results for some test cases. arXiv:1209.4752v1 [physics.comp-ph]

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Fundamental progress in systems biology can only be achieved if experimentalists and theoreticians closely collaborate. Mathematical models cannot be formulated precisely without deep knowledge of the experiments while complex biological systems can often not be understood fully without mathematical interpretation of the dynamic processes involved. In this article, we describe how these two approaches can be combined to gain new insights on one of the most extensively studied signal transduction pathways, the Janus kinase (JAK)/ signal transducer and activator of transcription (STAT) pathway. We focus on the parameters of a model describing how STAT proteins are transported from the membrane to the nucleus where STATs regulate gene expression. We discuss which parameters can be measured experimentally in different cell types and how the unknown parameters are estimated, what the limits of these techniques and how accurate the determinations are.

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Betrachtet man die Ergebnisse, so schwindet jede Besorgnis, Essigsfiure das spezifische Gewicht des alkoholischen Destillates und den Alkoholgehalt erniedrigen k6nne.Gehalt5 an fliieht~igen Siim-en in 100 ccm des alkoholischen Des~illates