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In peptide chemistry, there is the goal to produce pure biologically active peptides with the highest possible efficiency, even its possible by chemical synthesis purity and yield as a major problem. In this work, we focus to overcome above difficulty by novel synthetic approach. Angiotensin an oligopeptide is a hormone and a powerful dipsogen, which exhibits a wide range of biological activities, the 8-amino acid sequence Angiotensin-II and 6-amino acid sequence. Angiotensin-IV were synthesized by using 4-(2',4'-dimethoxyphenyl-Fmoc-aminomethyl)phenoxy resin, the modified Fmoc-chemistry and effective hydroxybenzenetriazole, N,N'-diisopropylcarbodiimide coupling and activation methods was used. The yield and chromatographic purities were compared.

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