No abstract

sidered to be more complex (Hokin, 1966). However, Tobias et al. (1962) have implicated the binding of cations by phospholipids in the physical changes occurring in the membrane in transport and potential phenomena.Lipids with ionized sulfate groups constitute an important component of membranes in the central nervous system. These sulfate groups are more strongly acidic than the lipid phosphate or carboxyl groups.

L-Pyroglutamyl-L-histidyl-glycine has been reported to be an anorexogenic agent in female mice. In this report the synthesis of this tripeptide is described. The synthetic material was injected into female and male mice and into male rats. In no instance did the animals decrease their food intake. Further, the weights of peptide-treated animals were the same as those of control (saline-treated) animals. The results suggest that L-pyroglutamyl-L-histidyl-glycine is not an anorexogenic agent.