No abstract

1,3-Dimethyl-5-nitro-5-hexahydropyrimidinyl)propionic acid methyl ester (I) was obtained with a 83% yield using a Mannich type reaction of 4-nitrobutanoic acid methyl ester with excess formalin and methylamine. It was found that compound I possesses low toxicity and shows antiarrhythmic activity on models of arrhythmia induced by intravenous injections of calcium chloride and aconitine in rats.

No abstract

5 Nitropentan 2 one reacts with methylamine and formaldehyde according to the Mannich reaction pattern to give 5 hexahydropyrimidinylcarbonyl substituted 1 nitro 3,7 diazabi cyclo[3.3.1]nonane in one experimental stage. When methyl 3 R 4 nitrobutanoates are used, the reaction stops after the formation of substituted 5 nitrohexahydropyrimidines in 40-98% yields.