Introduction. The effect of body mass index (BMI) on pregnancy outcome is not well established especially in a south Indian population. This study aimed to assess the link between maternal BMI and pregnancy outcomes. Materials and Methods.A prospective observational study was conducted among 150 pregnant women subjects in a south Indian tertiary care center for a period of 6 months after obtaining ethical M a n u s c r i p t a c c e p t e d f o r p u b l i c a t i o n 2 approval. Pregnant women aged 18 or above who were accepted and willing to provide written informed consent were included in the study. The relevant data were collected from patients and analyzed using SPSS version 16.Results. A higher proportion of participants (65.3%) had normal BMI, followed by overweight or obese (32%) and only 2.7% were underweight. Being overweight was significantly associated with depression (p = 0.032) and gestational diabetes (p = 0.000), but not with gestational hypertension and pre-eclampsia (p > 0.05) in the pregnant woman.Conclusions. The overweight and obesity were significantly associated with gestational diabetes and depression among pregnant women.